Pathophysiological mechanisms of diabetic retinopathy

Aim. To evaluate pathophysiological mechanisms in diabetic retinopathy.Material and methods. Factors of retinopathy pathogenesis, scientific reviews.Results. The evaluation found that early stages are characterized by histopathological changes, which include loss pericytes, basement membrane thickening, haemodynamic alterations leading to reduced vascular integrity. later complications, visual impairment, primarily due macular edema proliferative retinopathy. Also, the severity was associated with poorer metabolic control, demonstrated elevated HbA1c. Diabetic complications accompany accumulation advanced glycation end products tissues. Increased these has been reported epiretinal membranes use immunohistochemical technique. binding a high-affinity receptor pericytes exerts selective toxicity resulting their death. Vascular endothelial growth factor an important role intraocular neovascularization ischemic retinopathy.Conclusions. Early his topathological changes